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DIRECTIONS FOR USE
IMPORTANT: This information is approved as part of the Product Label. All instructions within this section must be carefully read in order to obtain safe and successful use of this product. ZOXIS is a systemic translaminar and protectant strobilurin fungicide and belongs to the Qol group of fungicides (FRAC mode of action code 11). It inhibits fungal respiration and, to protect against the development of resistance, should always be used in mixture or programmes with other fungicides with different modes of action. In addition to disease control, it can maintain green leaf area in crops longer than untreated crops and this can also lead to significant yield benefits. Applied as a preventative treatment when predictive tools indicate the likelihood of disease development or at the first sign of disease in the crop, it gives 4 – 6 weeks protection against susceptible diseases when applied to cereals at the stem elongation stage. Persistence may be even longer when applied to the flag leaf or the ear. Best results will be achieved from applications made in the earliest stage of disease development or as a protectant treatment following a disease risk assessment or the use of appropriate decision support systems. In dense crops, increase the water volume to improve coverage.

RESTRICTIONS
When using ZOXIS for disease control in cereals, it MUST be used in mixture with another product recommended for the control of the same target disease which
contains a fungicide with a different mode of action to reduce the risk of resistance developing. Mode of action codes are listed in the UK Pesticide Guide. Do not treat crops under stress. Possible causes of crop stress include poor soil or cultural conditions, adverse climatic conditions, water-logging or drought, pest or disease attack and nutrient deficiency. Consult processor before treating crops destined for processing. Certain apple varieties are highly sensitive to ZOXIS . As a precaution ZOXIS should not be applied when there is a risk of spray drift onto neighbouring apple crops. Spray equipment used to apply ZOXIS to other crops should not be used to treat apples

RESISTANCE MANAGEMENT
Good resistance management techniques should be adopted when using ZOXIS. Strategies should include mixtures or sequences with other fungicides with different modes of action where appropriate and non-chemical methods such as selection of varieties with inherent resistance to some diseases. Note the statutory limit on the number of applications of fungicides with the Qol mode of action in nominated crops. When applying these fungicides, use doses that will give good control. Strains of barley powdery mildew that are resistant to Qol fungicides are common in the UK and there is already a significant risk of widespread resistance to Qol fungicides in some Septoria tritici populations. The development of resistance in other pathogens cannot be ruled out and, where this occurs, reduced control is inevitable. Consult the FRAG UK guidelines on Qol fungicides.

MIXING and SPRAYING
Users should always inspect crops to assess disease development immediately before spraying. Before spraying it is important to check all hoses, filters and nozzles, and to ensure that the sprayer is clean and correctly set to give an even application at the correct volume. Half fill the spray tank with clean water. Begin agitation and add the required quantity of ZOXIS directly to the tank. Add the remainder of the water and agitate the mixture thoroughly before and during spraying. When using tank-mixtures, check whether there is an order of mixing in the compatibility section below. Wash out containers with an integrated pressure rinsing device or manually rinsing three times and add the washings to the spray tank. Do not leave the diluted spray in the tank for extended periods such as meal breaks or overnight.