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Some weeds are known to develop resistance to herbicides that have been used repeatedly. While the  development of herbicide resistance is well understood, it is not easily predicted. Therefore herbicides should be used in conjunction with the resistance management strategies in the area. Consult the local or State agricultural advisors for details. If herbicide resistance should develop in the area, this product used alone may not continue to provide sufficient levels of weed control. If the reduced levels of control cannot be attributed to improper application techniques, improper use rates, improper application timing, unfavorable weather conditions or abnormally high weed pressure, a resistant strain of weeds may have developed. To reduce the potential for weed resistance use this product in a rotation program with other classes of chemistry and modes of action. Always apply this product at the listed rates and in accordance with the use directions. Do not use less than listed label rates alone or in tank mixtures. Do not use reduced rates of the tank mix partner. For optimum performance, scout fields carefully and begin applications when weeds are smaller rather than larger. If resistance is suspected, contact the local or State agricultural advisors.

• F7488-1 is a soil-applied herbicide for the control of susceptible broadleaf, grass and sedge weeds.
• If adequate moisture (1/2" to 1") from rainfall or irrigation is not received within 7 to 10 days after the F7488-1 treatment, a shallow incorporation (less than 2"), may be needed to obtain desired weed control.
• When activating moisture is not received a planned POST application of a labeled herbicide will be needed for optimum weed control. If an activating rainfall CA" to 1.0") is not received F7488-1 will provide a reduced level of control of susceptible germinating weeds.
• Do not apply additional products containing sulfentrazone and pendimethalin to the crop unless specified in the individual crop section per twelve month season. Observe all instructions, crop restrictions, mixing directions, application precautions, replanting directions, rotational crop guidelines and other label information of each product when tank mixing with F7488-1. Proper handling instructions: F7488-1 may not be mixed or loaded within 50 feet of any wells (including abandoned wells and drainage wells), sinkholes, perennial or intermittent streams and rivers, and natural or impounded lakes and reservoirs. This setback does not apply to properly capped or plugged abandoned wells and does not apply to impervious pads or properly diked mixing/loading areas.
Operations that involve mixing, loading, rinsing, or washing of this product into or from pesticide handling or application equipment or containers within 50 feet of any well are prohibited unless conducted on an impervious pad constructed to withstand the weight of the heaviest load that may be positioned on or moved across the pad. Such a pad shall be designed and maintained to contain any product spills or equipment leaks, container or equipment rinse or wash water, and rainwater that may fall on the pad. Surface water shall not be allowed to either flow over or from the pad, which means the pad must be self-contained. The pad shall be sloped to facilitate material removal. An unroofed pad shall be of sufficient capacity to contain at a minimum 110% of the capacity of the largest pesticide container or application equipment on the pad. A pad that is covered by a roof of sufficient size to completely exclude precipitation from contact with the pad shall have a minimum containment capacity of 100% of the capacity of the largest pesticide container or application equipment on the pad. Containment capacities as described above shall be maintained at all times. The above specific minimum containment capacities do not apply to vehicles when delivering pesticide shipments to the mixing/loading site. States may have in effect additional requirements regarding wellhead setbacks and operational containment. Product must be used in a manner that will prevent back siphoning in wells, spills or improper disposal of excess pesticide, spray mixtures or rinsates.

It is a violation of Federal law to use this product in a manner inconsistent with its labeling.
Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application.
Do not apply more than the allowed amount of F7488-1 per acre per twelve-month period as stated in Table 2.
The twelve-month period is considered to begin upon the initial F7488-1 application.
For any requirements specific to your State or Tribe, consult the Agency responsible for pesticide regulation.
Extreme care must be exercised and the Crop Specific Use Directions followed. See specific crop section on F7488-1 label.

Mode of Action
F7488-1 provides two modes of action- Protoporpyrinogen Oxidase IX (PPO IX) and a meristematic inhibitor that interferes with the plant's cellular division or mitosis.

Mechanism of Action
Following the application of F7488-1 to soil, germinating seeds and seedlings take up F7488-1 from the soil solution. The amount of F7488-1 in soil solution available for weed uptake, is determined primarily by soil type, organic matter and soil pH. F7488-1 adsorbs to the clay and organic matter (OM) fractions of soils; effectively limiting the amount of active ingredient immediately available to control weeds. Influence of Soil type, organic matter and pH on F7488-1 Use Rates and Crop

Coarse and high pH >7.2 soils will exhibit increased weed control and crop response with F7488-1. It is important to know the soil type and pH levels of the field (or areas within a field) for application to determine the proper rate of F7488-1 for the crop Soil organic matter content and pH can vary widely and independently of soil type and requires an accurate analysis of representative soil samples to determine its content. It is important to note that irrigation with highly alkaline water (high pH) following a F7488-1 soil application can also significantly increase the amount of F7488-1 available in the soil solution. Irrigation with water having a pH greater than 7.2 could result in adverse crop response. This response will ultimately depend on initial F7488-1 application rate, timing, amount and pH of irrigation water and sensitivity of the crop and it's growth stage when irrigated. The risk of adverse crop response will lessen with the advance in growth stage among most crops.

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